BrinzolaMide Related CoMpound A

BrinzolaMide Related CoMpound A - Names and Identifiers

Name	(4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide
Synonyms	Brinzolamide Intermediate 1 -4-Hydroxy-2-(3-methoxypropyl) BrinzolaMide Related CoMpound A (4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2- -3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide (S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno-[3,2-e][1,2]thiazine-6-sulfonamide 1,1-di (S)-2-(3-Methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-4-ol-6-sulfonaMide-1,1- dioxide 4-hydroxy-2-(3-Methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonaMide 1,1-dioxide (S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-4H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxide (S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide (4S)-4-hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide (4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide,3,4-dihydro-4-hydroxy-2-(3-methoxypropyl)-, 1,1-dioxide, (4S)- 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonaMide,3,4-dihydro-4-hydroxy-2-(3-Methoxypropyl)-, 1,1-dioxide, (4S)-
CAS	154127-42-1
EINECS	807-123-6
InChI	InChI=1/C10H16N2O6S3/c1-18-4-2-3-12-6-8(13)7-5-9(20(11,14)15)19-10(7)21(12,16)17/h5,8,13H,2-4,6H2,1H3,(H2,11,14,15)/t8-/m1/s1

BrinzolaMide Related CoMpound A - Physico-chemical Properties

Molecular Formula	C10H16N2O6S3
Molar Mass	356.44
Density	1.575±0.06 g/cm3(Predicted)
Melting Point	112-115oC
Boling Point	612.4±65.0 °C(Predicted)
Flash Point	324.2°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	7.49E-16mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	9.53±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.615

BrinzolaMide Related CoMpound A - Reference Information

Application

(S)-3, 4-dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno [3,2-E]-1, 2-thiazin-6-sulfonamide 1, 1-dioxide is an intermediate of bulinzolamide. Brinzolamide [(4R) -4-(ethylamino) -3, 4-dihydro -2-(3-methoxypropyl)-2H-thieno [3,2-e] -1,2-thiazide -6-sulfonamido-1, 1-dioxide] is a carbonic anhydrase inhibitor that can be used to treat glaucoma.

Last Update：2024-04-09 18:58:34